USP18 expression based on
BRCA : Breast invasive carcinoma
Comparison Statistical significance
Normal-vs-Primary 1.62447832963153E-12
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Cancer stage information is not available/undetermined for 30 samples.
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Comparison
Statistical significance
Normal-vs-Stage1
4.36489733246503E-11
Normal-vs-Stage2
<1E-12
Normal-vs-Stage3
6.32827124036339E-15
Normal-vs-Stage4
1.501260E-03
Stage1-vs-Stage2
8.552300E-02
Stage1-vs-Stage3
4.132300E-02
Stage1-vs-Stage4
8.925600E-01
Stage2-vs-Stage3
3.854600E-01
Stage2-vs-Stage4
4.482600E-01
Stage3-vs-Stage4
2.448000E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Patient race information is not available for 109 samples.
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Comparison
Statistical significance
Normal-vs-Caucasian
1.6242562850266E-12
Normal-vs-AfricanAmerican
1.70419234279962E-12
Normal-vs-Asian
5.66410000000239E-05
Caucasian-vs-AfricanAmerican
5.572200E-02
Caucasian-vs-Asian
6.451900E-02
AfricanAmerican-vs-Asian
3.203200E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Patient gender information is not available for 10 samples.
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Comparison
Statistical significance
Normal-vs-Male
3.991800E-01
Normal-vs-Female
<1E-12
Male-vs-Female
2.124100E-02
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Patient age information is not available for 10 samples.
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Comparison
Statistical significance
Normal-vs-Age(21-40Yrs)
7.9830999588637E-09
Normal-vs-Age(41-60Yrs)
1.11022302462516E-16
Normal-vs-Age(61-80Yrs)
1.62447832963153E-12
Normal-vs-Age(81-100Yrs)
1.97867999999213E-05
Age(21-40Yrs)-vs-Age(41-60Yrs)
1.018100E-02
Age(21-40Yrs)-vs-Age(61-80Yrs)
2.422100E-02
Age(21-40Yrs)-vs-Age(81-100Yrs)
5.076200E-02
Age(41-60Yrs)-vs-Age(61-80Yrs)
4.722800E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)
8.091200E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)
9.172000E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
PR, ER or HER2 status by IHC is not available/not evaluated/ambiguous for 380 sample.
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Comparison
Statistical significance
Normal-vs-Luminal
1.62447832963153E-12
Normal-vs-HER2 Positive
2.41999999999187E-05
Normal-vs-TNBC
9.61086765727259E-12
Luminal-vs-HER2 Positive
2.486300E-02
Luminal-vs-TNBC
1.496840E-01
HER2 Positive-vs-TNBC
2.120800E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Menopause status is not available for 96 samples. Thirty four samples with intermediate menopause status are not considered in the above plot.
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Comparison
Statistical significance
Normal-vs-Pre-Menopause
1.62814206561279E-12
Normal-vs-Peri-Menopause
3.55560000000477E-05
Normal-vs-Post-Menopause
1.62447832963153E-12
Pre-Menopause-vs-Peri-Menopause
9.719600E-01
Pre-Menopause-vs-Post-Menopause
3.406600E-01
Peri-Menopause-vs-Post-Menopause
6.471400E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
BRCA : Breast invasive carcinoma
Subtype descriptions
TNBC-BL1 TNBC Basal-like 1
TNBC-BL2 TNBC Basal-like 2
TNBC-IM TNBC Immunomodulatory
TNBC-M TNBC Mesenchymal
TNBC-MSL TNBC mesenchymal stem-like
TNBC-LAR TNBC luminal androgen receptor
TNBC-UNS TNBC unspecified
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Comparison
Statistical significance
Normal-vs-Luminal
1.62447832963153E-12
Normal-vs-HER2Pos
2.41999999999187E-05
Normal-vs-TNBC-BL1
6.101900E-03
Normal-vs-TNBC-BL2
6.502900E-03
Normal-vs-TNBC-IM
2.991400E-04
Normal-vs-TNBC-LAR
6.040000E-02
Normal-vs-TNBC-MSL
1.354000E-01
Normal-vs-TNBC-M
1.619600E-03
Normal-vs-TNBC-UNS
7.245100E-04
Luminal-vs-HER2Pos
2.486300E-02
Luminal-vs-TNBC-BL1
5.436000E-02
Luminal-vs-TNBC-BL2
9.326600E-01
Luminal-vs-TNBC-IM
1.012090E-02
Luminal-vs-TNBC-LAR
7.264900E-03
Luminal-vs-TNBC-MSL
8.628800E-01
Luminal-vs-TNBC-M
7.985600E-01
Luminal-vs-TNBC-UNS
4.651600E-01
HER2Pos-vs-TNBC-BL1
1.697850E-01
HER2Pos-vs-TNBC-BL2
1.083840E-01
HER2Pos-vs-TNBC-IM
5.254000E-01
HER2Pos-vs-TNBC-LAR
1.061770E-03
HER2Pos-vs-TNBC-MSL
3.066800E-01
HER2Pos-vs-TNBC-M
7.027600E-02
HER2Pos-vs-TNBC-UNS
3.680400E-02
TNBC-BL1-vs-TNBC-BL2
5.851900E-02
TNBC-BL1-vs-TNBC-IM
4.383400E-01
TNBC-BL1-vs-TNBC-LAR
1.263870E-02
TNBC-BL1-vs-TNBC-MSL
1.136770E-01
TNBC-BL1-vs-TNBC-M
4.955900E-02
TNBC-BL1-vs-TNBC-UNS
4.094100E-02
TNBC-BL2-vs-TNBC-IM
5.030100E-02
TNBC-BL2-vs-TNBC-LAR
8.788000E-02
TNBC-BL2-vs-TNBC-MSL
8.730400E-01
TNBC-BL2-vs-TNBC-M
8.877400E-01
TNBC-BL2-vs-TNBC-UNS
7.092600E-01
TNBC-IM-vs-TNBC-LAR
1.820430E-03
TNBC-IM-vs-TNBC-MSL
1.513150E-01
TNBC-IM-vs-TNBC-M
3.496400E-02
TNBC-IM-vs-TNBC-UNS
2.166300E-02
TNBC-LAR-vs-TNBC-MSL
3.296000E-01
TNBC-LAR-vs-TNBC-M
6.778200E-02
TNBC-LAR-vs-TNBC-UNS
7.649700E-02
TNBC-MSL-vs-TNBC-M
9.650000E-01
TNBC-MSL-vs-TNBC-UNS
9.121400E-01
TNBC-M-vs-TNBC-UNS
8.172200E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Tumor histology is not available for 3 samples.
Subtype descriptions
IDC Infiltrating Ductal Carcinoma
ILC Infiltrating Lobular Carcinoma
Mixed Mixed histology
Mucinous Mucinous Carcinoma
Medullary Medullary Carcinoma
Metaplastic Metaplastic Carcinoma
INOS Infiltrating Carcinoma NOS
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Comparison
Statistical significance
Normal-vs-IDC
<1E-12
Normal-vs-ILC
1.21940000319398E-08
Normal-vs-Mixed
1.787770E-04
Normal-vs-Other
9.366200E-04
Normal-vs-Mucinous
1.877930E-02
Normal-vs-Metaplastic
9.330600E-01
Normal-vs-INOS
N/A
Normal-vs-Medullary
3.223500E-02
IDC-vs-ILC
3.76454423189898E-12
IDC-vs-Mixed
1.800870E-03
IDC-vs-Other
9.594000E-02
IDC-vs-Mucinous
5.277000E-01
IDC-vs-Metaplastic
3.39069999999442E-06
IDC-vs-INOS
N/A
IDC-vs-Medullary
6.075000E-01
ILC-vs-Mixed
4.143000E-01
ILC-vs-Other
1.825220E-01
ILC-vs-Mucinous
9.816100E-02
ILC-vs-Metaplastic
1.202100E-02
ILC-vs-INOS
N/A
ILC-vs-Medullary
1.232190E-02
Mixed-vs-Other
5.765200E-01
Mixed-vs-Mucinous
1.697570E-01
Mixed-vs-Metaplastic
2.810500E-02
Mixed-vs-INOS
N/A
Mixed-vs-Medullary
2.503800E-02
Other-vs-Mucinous
2.708600E-01
Other-vs-Metaplastic
4.519400E-03
Other-vs-INOS
N/A
Other-vs-Medullary
2.215800E-01
Mucinous-vs-Metaplastic
2.190300E-02
Mucinous-vs-INOS
N/A
Mucinous-vs-Medullary
9.198800E-01
Metaplastic-vs-INOS
N/A
Metaplastic-vs-Medullary
3.663600E-02
INOS-vs-Medullary
N/A
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Nodal metastais status is not available for 2 samples and cancer in nearby lymph nodes cannot be measured (NX) in 20 samples.
pathologic_N descriptions
N0 No regional lymph node metastasis
N1 Metastases in 1 to 3 axillary lymph nodes
N2 Metastases in 4 to 9 axillary lymph nodes
N3 Metastases in 10 or more axillary lymph nodes
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Comparison
Statistical significance
Normal-vs-N0
<1E-12
Normal-vs-N1
1.62447832963153E-12
Normal-vs-N2
1.46559986369255E-10
Normal-vs-N3
2.438400E-04
N0-vs-N1
7.537800E-01
N0-vs-N2
1.343030E-01
N0-vs-N3
4.613400E-01
N1-vs-N2
1.992570E-01
N1-vs-N3
5.340800E-01
N2-vs-N3
8.779800E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma
Note
Whole exome sequencing data is not available for 65 samples.
TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison
Statistical significance
Normal-vs-TP53-Mutant
<1E-12
Normal-vs-TP53-NonMutant
<1E-12
TP53-Mutant-vs-TP53-NonMutant
3.80870000005196E-06
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap