TOPBP1 expression based on
UCEC : Uterine corpus endometrial carcinoma
Comparison Statistical significance Normal-vs-Primary 1.41979761281164E-11
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma
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Comparison Statistical significance
Normal-vs-Stage1
1.18699999995808E-06
Normal-vs-Stage2
1.626560E-04
Normal-vs-Stage3
1.06940001298739E-09
Normal-vs-Stage4
1.659400E-03
Stage1-vs-Stage2
4.031600E-02
Stage1-vs-Stage3
2.758600E-04
Stage1-vs-Stage4
2.986400E-02
Stage2-vs-Stage3
3.410000E-01
Stage2-vs-Stage4
6.806200E-01
Stage3-vs-Stage4
7.217200E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma Note
Patient race information is not available for 32 samples. Nine samples from Native Hawaiian and four samples from American Indians are not considered in the above plot.
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Comparison Statistical significance
Normal-vs-Caucasian
1.76879999536084E-09
Normal-vs-AfricanAmerican
3.87180000283038E-08
Normal-vs-Asian
1.908580E-01
Caucasian-vs-AfricanAmerican
1.565920E-02
Caucasian-vs-Asian
4.218200E-01
AfricanAmerican-vs-Asian
3.383600E-02
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma Note
Patient BMI information is not available for 31 samples.
Descriptions Normal weight BMI greater than equal to 18.5 and BMI less than 25
Extereme weight
BMI greater than equal to 25 and BMI less than 30 Obese BMI greater than equal to 30 and BMI less than 40
Extreme Obese
BMI greater than 40
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Comparison Statistical significance
Normal-vs-Normal_Weight
3.45829997971947E-09
Normal-vs-Extreme_Weight
2.188500E-04
Normal-vs-Obese
1.59450000003503E-06
Normal-vs-Extreme_Obese
6.08629999999666E-05
Normal_Weight-vs-Extreme_Weight
1.482300E-02
Normal_Weight-vs-Obese
2.229700E-02
Normal_Weight-vs-Extreme_Obese
4.573900E-02
Extreme_Weight-vs-Obese
7.371000E-01
Extreme_Weight-vs-Extreme_Obese
6.864000E-01
Obese-vs-Extreme_Obese
9.155800E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma Note
Patient age information is not available for 3 samples.
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Comparison Statistical significance
Normal-vs-Age(21-40Yrs)
4.231400E-01
Normal-vs-Age(41-60Yrs)
2.69779999995112E-06
Normal-vs-Age(61-80Yrs)
8.9708018791157E-11
Normal-vs-Age(81-100Yrs)
8.09720000000125E-05
Age(21-40Yrs)-vs-Age(41-60Yrs)
2.837400E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)
1.310590E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)
5.018000E-02
Age(41-60Yrs)-vs-Age(61-80Yrs)
2.019600E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)
1.157370E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)
4.121000E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma Note
Menopause status is not available for 30 samples. Seventeen samples with intermediate menopause status are not considered in the above plot.
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Comparison Statistical significance
Normal-vs-Pre-Menopause
9.788200E-02
Normal-vs-Peri-Menopause
1.273910E-02
Normal-vs-Post-Menopause
4.74059680399819E-11
Pre-Menopause-vs-Peri-Menopause
9.715800E-02
Pre-Menopause-vs-Post-Menopause
4.924500E-02
Peri-Menopause-vs-Post-Menopause
6.187200E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma
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Comparison Statistical significance
Normal-vs-Endometrioid
8.89690000005494E-07
Normal-vs-Serous
2.10687023383116E-12
Normal-vs-Mixed serous and endometrioid
6.564200E-03
Endometrioid -vs-Serous
2.18389999973034E-07
Endometrioid-vs-Mixed serous and endometrioid
3.904400E-02
Serous-vs-Mixed serous and endometrioid
3.877000E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
UCEC : Uterine corpus endometrial carcinoma Note
Whole exome sequencing data is not available for 5 samples.
TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison Statistical significance
Normal-vs-TP53-Mutant
1.62447832963153E-12
Normal-vs-TP53-NonMutant
2.664100E-03
TP53-Mutant-vs-TP53-NonMutant
2.66453525910038E-15
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
