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Adrenocortical carcinoma

Bladder urothelial carcinoma

Brain lower grade glioma

Breast invasive carcinoma

Metastatic breast cancer

Cervical squamous cell carcinoma

Cholangiocarcinoma

Colon adenocarcinoma

Esophageal carcinoma

Glioblastoma multiforme

Head and Neck squamous cell carcinoma

Kidney Chromophobe

Kidney renal clear cell carcinoma

Kidney renal papillary cell carcinoma

Acute myeloid leukemia

Liver hepatocellular carcinoma

Lung adenocarcinoma

Lung squamous cell carcinoma

Lymphoid Neoplasm Diffuse Large B-cell Lymphoma

Ovarian serous cystadenocarcinoma

Pancreatic adenocarcinoma

Pheochromocytoma and Paraganglioma

Prostate adenocarcinoma

Metastatic prostate cancer

Rectum adenocarcinoma

Skin Cutaneous Melanoma

Stomach adenocarcinoma

Testicular Germ Cell Tumors

Thyroid carcinoma

Uterine Carcinosarcoma

Uterine Corpus Endometrial Carcinoma

PRSS16 expression based on

Comparison	Statistical significance
Normal-vs-Primary	1.62436730732907E-12

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

Note Cancer stage information is not available for 2 samples.

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Comparison	Statistical significance
Normal-vs-Stage1	1.11022302462516E-16
Normal-vs-Stage2	7.25890003661078E-09
Normal-vs-Stage3	<1E-12
Normal-vs-Stage4	1.64257496493292E-12
Stage1-vs-Stage2	1.849640E-01
Stage1-vs-Stage3	9.221500E-02
Stage1-vs-Stage4	2.327000E-01
Stage2-vs-Stage3	2.694100E-02
Stage2-vs-Stage4	6.226300E-02
Stage3-vs-Stage4	9.237600E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

Note Patient race information is not available for 92 samples and one samples from American Indians not included in the above plot.

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Comparison	Statistical significance
Normal-vs-Caucasian	<1E-12
Normal-vs-AfricanAmerican	6.40299999999927E-05
Normal-vs-Asian	1.85018667053782E-12
Caucasian-vs-AfricanAmerican	7.161200E-01
Caucasian-vs-Asian	5.344600E-01
AfricanAmerican-vs-Asian	9.308200E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

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Comparison	Statistical significance
Normal-vs-Male	<1E-12
Normal-vs-Female	1.62447832963153E-12
Male-vs-Female	8.786000E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

Note Seventeen samples from patient below 21 years not considered in above plot.

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Comparison	Statistical significance
Normal-vs-Age(21-40Yrs)	1.62447832963153E-12
Normal-vs-Age(41-60Yrs)	<1E-12
Normal-vs-Age(61-80Yrs)	1.62447832963153E-12
Normal-vs-Age(81-100Yrs)	2.00739999999255E-05
Age(21-40Yrs)-vs-Age(41-60Yrs)	9.898800E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)	6.404200E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)	8.458200E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)	6.851800E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)	8.787800E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)	9.978200E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

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Comparison	Statistical significance
Classical-VS-Tall	3.53470000047373E-07
Classical-VS-Follicular	1.91626999999084E-05
Classical-VS-Other	1.624640E-01
Classical-VS-Normal	1.62436730732907E-12
Tall-VS-Follicular	1.13710152405133E-11
Tall-VS-Other	1.624480E-02
Tall-VS-Normal	1.62447832963153E-12
Follicular-VS-Other	6.927800E-01
Follicular-VS-Normal	5.34570000043644E-07
Other-VS-Normal	2.036600E-03

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

Note Cancer in nearby lymph nodes cannot be measured (NX) in 50 samples.

pathologic_N descriptions
N0	No regional lymph node metastasis	N1	Metastases in 1 to 3 axillary lymph nodes
N2	Metastases in 4 to 9 axillary lymph nodes	N3	Metastases in 10 or more axillary lymph nodes

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Comparison	Statistical significance
Normal-vs-N0	<1E-12
Normal-vs-N1	4.44089209850063E-16
N0-vs-N1	8.035700E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

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