APPL2 expression based on
LUSC : Lung squamous cell carcinoma
Comparison Statistical significance Normal-vs-Primary 1.36429756381062E-11
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Cancer stage information is not available for 11 samples.
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Comparison Statistical significance
Normal-vs-Stage1
3.04560043851154E-10
Normal-vs-Stage2
6.68120000435479E-08
Normal-vs-Stage3
7.870799999532E-07
Normal-vs-Stage4
1.621360E-01
Stage1-vs-Stage2
5.592000E-01
Stage1-vs-Stage3
8.077000E-01
Stage1-vs-Stage4
7.210500E-02
Stage2-vs-Stage3
8.134000E-01
Stage2-vs-Stage4
1.279600E-01
Stage3-vs-Stage4
3.433000E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Patient race information is not available for 121 samples.
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Comparison Statistical significance
Normal-vs-Caucasian
8.23141554917584E-12
Normal-vs-AfricanAmerican
5.498200E-02
Normal-vs-Asian
2.629200E-01
Caucasian-vs-AfricanAmerican
1.245750E-01
Caucasian-vs-Asian
2.103600E-01
AfricanAmerican-vs-Asian
6.717600E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Patient gender information is not available for 9 samples.
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Comparison Statistical significance
Normal-vs-Male
4.36319869123736E-11
Normal-vs-Female
1.19830000000487E-06
Male-vs-Female
7.214000E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Patient age information is not available for 17 samples.
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Comparison Statistical significance
Normal-vs-Age(21-40Yrs)
4.398000E-01
Normal-vs-Age(41-60Yrs)
5.29230004264747E-09
Normal-vs-Age(61-80Yrs)
2.44219977574289E-10
Normal-vs-Age(81-100Yrs)
6.075000E-03
Age(21-40Yrs)-vs-Age(41-60Yrs)
1.499560E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)
2.507800E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)
1.759780E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)
3.792600E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)
7.191000E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)
9.324800E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Smoking status is not available for 17 samples.
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Comparison Statistical significance
Normal-vs-Non smoker
5.283800E-02
Normal-vs-Smoker
1.03669961504238E-10
Normal-vs-Reformed smoker1
6.751600E-04
Normal-vs-Reformed smoker2
5.60539947791483E-10
Non smoker-vs-Smoker
1.484190E-01
Non smoker-vs-Reformed smoker1
9.136200E-01
Non smoker-vs-Reformed smoker2
3.760200E-01
Smoker-vs-Reformed smoker1
1.699290E-03
Smoker-vs-Reformed smoker2
1.224610E-01
Reformed smoker1-vs-Reformed smoker2
2.988200E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Tumor histology is not available for 2 samples.
Subtype descriptions NOS Lung Squamous Cell Carcinoma-Not Otherwise Specified (NOS)
Basaloid Lung Basaloid Squamous Cell Carcinoma Papillary Lung Papillary Squamous Cell Carcinoma
SmallCell Lung Small Cell Squamous Cell Carcinoma
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Comparison Statistical significance
Normal-vs-NOS
2.06269445968132E-11
Normal-vs-Basaloid
5.98109999999652E-05
Normal-vs-Papillary
7.314600E-01
Normal-vs-SmallCell
N/A
NOS-vs-Basaloid
6.586000E-02
NOS-vs-Papillary
3.347400E-01
NOS-vs-SmallCell
N/A
Basaloid-vs-Papillary
3.435600E-02
Basaloid-vs-SmallCell
N/A
Papillary-vs-SmallCell
N/A
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Nodal metastais status is not available for 1 sample and cancer in nearby lymph nodes cannot be measured (NX) in 6 samples.
pathologic_N descriptions N0 No regional lymph node metastasis
N1 Metastases in 1 to 3 axillary lymph nodes N2 Metastases in 4 to 9 axillary lymph nodes
N3 Metastases in 10 or more axillary lymph nodes
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Comparison Statistical significance
Normal-vs-N0
9.50729495130531E-11
Normal-vs-N1
3.0298999975642E-09
Normal-vs-N2
5.396600E-03
Normal-vs-N3
5.337200E-03
N0-vs-N1
5.684000E-01
N0-vs-N2
4.886400E-01
N0-vs-N3
9.390200E-01
N1-vs-N2
3.132000E-01
N1-vs-N3
9.553600E-01
N2-vs-N3
7.301400E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LUSC : Lung squamous cell carcinoma Note
Whole exome sequencing data is not available for 16 samples.
TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison Statistical significance
Normal-vs-TP53-Mutant
1.51545442861334E-12
Normal-vs-TP53-NonMutant
3.81350000000502E-05
TP53-Mutant-vs-TP53-NonMutant
1.696030E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
