SMAD4 expression based on
LIHC : Liver hepatocellular carcinoma
Comparison Statistical significance Normal-vs-Primary 4.55913085062321E-12
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Cancer stage information is not available for 31 samples.
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Comparison Statistical significance
Normal-vs-Stage1
4.47940000003477E-06
Normal-vs-Stage2
2.4951999999967E-05
Normal-vs-Stage3
2.36980000001275E-06
Normal-vs-Stage4
3.279600E-01
Stage1-vs-Stage2
2.653600E-01
Stage1-vs-Stage3
1.716300E-02
Stage1-vs-Stage4
8.436200E-01
Stage2-vs-Stage3
1.518590E-01
Stage2-vs-Stage4
8.782400E-01
Stage3-vs-Stage4
5.665200E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Patient race information is not available for 19 samples. One sample from American Indians are not considered in the above plot.
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Comparison Statistical significance
Normal-vs-Caucasian
3.32439997752232E-09
Normal-vs-AfricanAmerican
2.734400E-02
Normal-vs-Asian
9.73160000361517E-08
Caucasian-vs-AfricanAmerican
7.478800E-01
Caucasian-vs-Asian
8.502600E-01
AfricanAmerican-vs-Asian
7.214200E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Patient gender information is not available for 9 samples.
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Comparison Statistical significance
Normal-vs-Male
2.1105999947757E-08
Normal-vs-Female
8.38229996524831E-09
Male-vs-Female
1.021580E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Patient BMI information is not available for 41 samples.
Descriptions Normal weight BMI greater than equal to 18.5 and BMI less than 25
Extereme weight
BMI greater than equal to 25 and BMI less than 30 Obese BMI greater than equal to 30 and BMI less than 40
Extreme Obese
BMI greater than 40
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Comparison Statistical significance
Normal-vs-Normal_Weight
3.07180000325147E-08
Normal-vs-Extreme_Weight
2.964400E-03
Normal-vs-Obese
4.38910000000181E-05
Normal-vs-Extreme_Obese
4.965000E-01
Normal_Weight-vs-Extreme_Weight
4.922200E-02
Normal_Weight-vs-Obese
7.474400E-01
Normal_Weight-vs-Extreme_Obese
2.344600E-01
Extreme_Weight-vs-Obese
1.534590E-01
Extreme_Weight-vs-Extreme_Obese
5.720000E-01
Obese-vs-Extreme_Obese
1.854630E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Patient age information is not available for 9 samples and four sample from patient aged below 21 years not considered in the above plot.
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Comparison Statistical significance
Normal-vs-Age(21-40Yrs)
3.479800E-02
Normal-vs-Age(41-60Yrs)
7.4064998578649E-10
Normal-vs-Age(61-80Yrs)
3.16219999996203E-06
Normal-vs-Age(81-100Yrs)
1.366320E-02
Age(21-40Yrs)-vs-Age(41-60Yrs)
6.910600E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)
2.877400E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)
8.433400E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)
3.110100E-02
Age(41-60Yrs)-vs-Age(81-100Yrs)
8.535400E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)
3.225400E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Tumor grade information is not available for 14 samples and undetermined for 5 samples.
Subtype descriptions Grade 1 Well differentiated (low grade)
Grade 2 Moderately differentiated (intermediate grade) Grade 3 Poorly differentiated (high grade)
Grade 4 Undifferentiated (high grade)
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Comparison Statistical significance
Normal-vs-Grade 1
2.281500E-03
Normal-vs-Grade 2
6.69699999900075E-08
Normal-vs-Grade 3
3.49979999980654E-07
Normal-vs-Grade 4
2.236000E-01
Grade 1-vs-Grade 2
5.671800E-01
Grade 1-vs-Grade 3
9.159200E-01
Grade 1-vs-Grade 4
6.842000E-01
Grade 2-vs-Grade 3
3.105400E-01
Grade 2-vs-Grade 4
8.459600E-01
Grade 3-vs-Grade 4
5.943800E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma
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Comparison Statistical significance
Normal-vs-Hepatocellular carcinoma
4.15834033873352E-12
Normal-vs-Fibrolamellar carcinoma
4.643600E-02
Normal-vs-Hepatocholangio carcinoma (Mixed)
7.129900E-02
Hepatocellular carcinoma-vs-Fibrolamellar carcinoma
1.186190E-01
Hepatocellular carcinoma-vs-Hepatocholangio carcinoma (Mixed)
1.443800E-01
Fibrolamellar carcinoma-vs-Hepatocholangio carcinoma (Mixed)
1.858050E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Nodal metastais status is not available for 1 sample and cancer in nearby lymph nodes cannot be measured (NX) in 114 samples.
pathologic_N descriptions N0 No regional lymph node metastasis
N1 Metastases in 1 to 3 axillary lymph nodes N2 Metastases in 4 to 9 axillary lymph nodes
N3 Metastases in 10 or more axillary lymph nodes
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Comparison Statistical significance
Normal-vs-N0
5.05069985834439E-10
Normal-vs-N1
1.730180E-01
N0-vs-N1
3.020600E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
LIHC : Liver hepatocellular carcinoma Note
Whole exome sequencing data is not available for 11 samples.
TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison Statistical significance
Normal-vs-TP53-Mutant
5.38159999896592E-08
Normal-vs-TP53-NonMutant
6.1596000522357E-09
TP53-Mutant-vs-TP53-NonMutant
5.704200E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
