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PRSS16 expression based on

KIRC : Kidney renal clear cell carcinoma

Comparison	Statistical significance
Normal-vs-Primary	1.000470E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

Note Cancer stage information is not available for 2 samples.

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Comparison	Statistical significance
Normal-vs-Stage1	1.039810E-02
Normal-vs-Stage2	4.453600E-02
Normal-vs-Stage3	2.636300E-02
Normal-vs-Stage4	5.418800E-01
Stage1-vs-Stage2	5.946600E-01
Stage1-vs-Stage3	9.477600E-01
Stage1-vs-Stage4	1.120250E-01
Stage2-vs-Stage3	6.159800E-01
Stage2-vs-Stage4	1.300970E-01
Stage3-vs-Stage4	1.455230E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

Note Patient race information is not available for 7 samples.

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Comparison	Statistical significance
Normal-vs-Caucasian	9.476400E-03
Normal-vs-AfricanAmerican	5.324600E-01
Normal-vs-Asian	3.382600E-01
Caucasian-vs-AfricanAmerican	2.743400E-01
Caucasian-vs-Asian	9.954800E-01
AfricanAmerican-vs-Asian	6.965800E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

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Comparison	Statistical significance
Normal-vs-Male	9.657500E-03
Normal-vs-Female	4.564300E-02
Male-vs-Female	7.517000E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

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Comparison	Statistical significance
Normal-vs-Age(21-40Yrs)	5.866400E-01
Normal-vs-Age(41-60Yrs)	5.195800E-03
Normal-vs-Age(61-80Yrs)	4.729600E-02
Normal-vs-Age(81-100Yrs)	2.534000E-01
Age(21-40Yrs)-vs-Age(41-60Yrs)	3.881800E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)	6.660200E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)	6.089800E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)	2.650200E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)	9.237400E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)	7.076600E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

Note Tumor grade information is not available for 3 samples and undetermined for 5 samples.

Subtype descriptions
Grade 1	Well differentiated (low grade)	Grade 2	Moderately differentiated (intermediate grade)
Grade 3	Poorly differentiated (high grade)	Grade 4	Undifferentiated (high grade)

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Comparison	Statistical significance
Normal-vs-Grade 1	5.278800E-01
Normal-vs-Grade 2	2.878400E-03
Normal-vs-Grade 3	2.965900E-02
Normal-vs-Grade 4	9.820200E-01
Grade 1-vs-Grade 2	6.835800E-01
Grade 1-vs-Grade 3	8.751000E-01
Grade 1-vs-Grade 4	5.357600E-01
Grade 2-vs-Grade 3	3.854000E-01
Grade 2-vs-Grade 4	5.523000E-03
Grade 3-vs-Grade 4	3.197600E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

NOTE Subtype information is not available for 153 samples.

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Comparison	Statistical significance
Normal-vs-ccA subtype	2.366200E-04
Normal-vs-ccB subtype	8.214100E-02
ccA subtype-vs-ccB subtype	2.216200E-02

KIRC subtypes: Brooks SA et al, ClearCode34: A prognostic risk predictor for localized clear cell renal cell carcinoma. Eur Urol. 2014 Jul;66(1):77-84. doi: 10.1016/j.eururo.2014.02.035

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

KIRC : Kidney renal clear cell carcinoma

Note Cancer in nearby lymph nodes cannot be measured (NX) in 277 samples.

pathologic_N descriptions
N0	No regional lymph node metastasis	N1	Metastases in 1 to 3 axillary lymph nodes
N2	Metastases in 4 to 9 axillary lymph nodes	N3	Metastases in 10 or more axillary lymph nodes

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Comparison	Statistical significance
Normal-vs-N0	7.796700E-03
Normal-vs-N1	9.350400E-01
N0-vs-N1	9.790300E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

Select cancer

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

KIRC : Kidney renal clear cell carcinoma

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