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Select cancer

PRSS16 expression based on

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Comparison	Statistical significance
Normal-vs-Primary	3.89419999999863E-05

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Note Cancer stage information is not available for 8 samples.

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Comparison	Statistical significance
Normal-vs-Stage1	6.92570000015991E-07
Normal-vs-Stage2	1.03140052054584E-10
Normal-vs-Stage3	1.06889999962334E-07
Normal-vs-Stage4	3.812200E-04
Stage1-vs-Stage2	3.842400E-01
Stage1-vs-Stage3	9.030500E-02
Stage1-vs-Stage4	4.350800E-01
Stage2-vs-Stage3	3.923600E-02
Stage2-vs-Stage4	3.102800E-01
Stage3-vs-Stage4	7.635000E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Note Patient race information is not available for 37 samples. Two samples from Native Hawaiian and seven samples from American Indians are not considered in the above plot.

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Comparison	Statistical significance
Normal-vs-Caucasian	7.88039999921608E-08
Normal-vs-AfricanAmerican	5.49539999949999E-07
Normal-vs-Asian	1.509800E-02
Caucasian-vs-AfricanAmerican	3.621200E-01
Caucasian-vs-Asian	2.015800E-01
AfricanAmerican-vs-Asian	8.910800E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Note Patient BMI information is not available for 46 samples.

Descriptions
Normal weight	BMI greater than equal to 18.5 and BMI less than 25	Extereme weight	BMI greater than equal to 25 and BMI less than 30
Obese	BMI greater than equal to 30 and BMI less than 40	Extreme Obese	BMI greater than 40

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Comparison	Statistical significance
Normal-vs-Normal_Weight	2.64770000368841E-08
Normal-vs-Extreme_Weight	2.8974000976234E-10
Normal-vs-Obese	1.60250035463605E-10
Normal-vs-Extreme_Obese	2.714000E-02
Normal_Weight-vs-Extreme_Weight	1.444960E-01
Normal_Weight-vs-Obese	2.164000E-01
Normal_Weight-vs-Extreme_Obese	4.006600E-01
Extreme_Weight-vs-Obese	9.762800E-01
Extreme_Weight-vs-Extreme_Obese	1.283590E-01
Obese-vs-Extreme_Obese	6.070300E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Note Patient age information is not available for 1 sample. One sample from patients below 21 years are not considered in above plot.

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Comparison	Statistical significance
Normal-vs-Age(21-40Yrs)	1.8428000003734E-07
Normal-vs-Age(41-60Yrs)	4.7623999965829E-08
Normal-vs-Age(61-80Yrs)	1.27440002994916E-09
Normal-vs-Age(81-100Yrs)	1.731230E-01
Age(21-40Yrs)-vs-Age(41-60Yrs)	3.817400E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)	2.423400E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)	3.617200E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)	5.162600E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)	6.037400E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)	7.755000E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Note Histological subtype information is not available for 1 sample.

Subtype descriptions
Adenosquamous	Cervical adenosquamous carcinoma	Squamous-cell	Cervical squamous cell carcinoma
Endocervical	Endocervical adenocarcinoma of the usual type \| Endocervical type of adenocarcinoma	Mucinous	Mucinous adenocarcinoma of endocervical type
Endometrioid	Endometrioid adenocarcinoma of endocervix

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Comparison	Statistical significance
Adenosquamous-VS-Squamous-cell	9.242600E-01
Adenosquamous-VS-Endocervical	2.369400E-01
Adenosquamous-VS-Endometrioid	6.009400E-01
Adenosquamous-VS-Mucinous	4.092200E-02
Adenosquamous-VS-Normal	7.065600E-02
Squamous-cell-VS-Endocervical	1.030120E-02
Squamous-cell-VS-Endometrioid	3.548400E-01
Squamous-cell-VS-Mucinous	7.158300E-04
Squamous-cell-VS-Normal	5.80310000000139E-05
Endocervical-VS-Endometrioid	1.727370E-01
Endocervical-VS-Mucinous	1.908790E-01
Endocervical-VS-Normal	3.889499999854E-07
Endometrioid-VS-Mucinous	4.156200E-02
Endometrioid-VS-Normal	4.515200E-01
Mucinous-VS-Normal	5.84120000035604E-07

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

Subtype descriptions
Grade 1	Well differentiated (low grade)	Grade 2	Moderately differentiated (intermediate grade)
Grade 3	Poorly differentiated (high grade)	Grade 4	Undifferentiated (high grade)

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Comparison	Statistical significance
Normal-vs-Grade 1	N/A
Normal-vs-Grade 2	N/A
Normal-vs-Grade 3	N/A
Normal-vs-Grade 4	N/A
Grade 1-vs-Grade 2	3.369000E-01
Grade 1-vs-Grade 3	1.954160E-01
Grade 1-vs-Grade 4	N/A
Grade 2-vs-Grade 3	1.675620E-01
Grade 2-vs-Grade 4	N/A
Grade 3-vs-Grade 4	N/A

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

CESC : Cervical squamous cell carcinoma

* Please note that low number(<10) of normal samples considered.

Note Nodal metastais status is not available for 46 samples and cancer in nearby lymph nodes cannot be measured (NX) in 66 samples.

pathologic_N descriptions
N0	No regional lymph node metastasis	N1	Metastases in 1 to 3 axillary lymph nodes
N2	Metastases in 4 to 9 axillary lymph nodes	N3	Metastases in 10 or more axillary lymph nodes

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Comparison	Statistical significance
Normal-vs-N0	7.15610004586864E-09
Normal-vs-N1	6.2599999961499E-08
N0-vs-N1	6.111700E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH

Select cancer

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

CESC : Cervical squamous cell carcinoma

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