PSEN1 expression based on
BRCA : Breast invasive carcinoma Statistics: Unpaired two sample T-test was employed to evaluate levels of significance in expression level between any two sample groups
Comparison Statistical significance Normal-vs-Primary 5.25830046171905E-10
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Cancer stage information is not available/undetermined for 30 samples.
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Comparison Statistical significance
Normal-vs-Stage1
3.70640000024736E-07
Normal-vs-Stage2
1.97400000012671E-07
Normal-vs-Stage3
1.70730000004227E-06
Normal-vs-Stage4
6.118000E-01
Stage1-vs-Stage2
2.235600E-01
Stage1-vs-Stage3
7.332800E-01
Stage1-vs-Stage4
1.909980E-02
Stage2-vs-Stage3
4.140800E-01
Stage2-vs-Stage4
8.183700E-02
Stage3-vs-Stage4
4.844100E-02
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Patient race information is not available for 109 samples.
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Comparison Statistical significance
Normal-vs-Caucasian
5.48450174164827E-14
Normal-vs-AfricanAmerican
6.422000E-04
Normal-vs-Asian
6.987900E-02
Caucasian-vs-AfricanAmerican
<1E-12
Caucasian-vs-Asian
1.226200E-02
AfricanAmerican-vs-Asian
3.418300E-04
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Patient gender information is not available for 10 samples.
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Comparison Statistical significance
Normal-vs-Male
6.358400E-01
Normal-vs-Female
2.63770005837216E-10
Male-vs-Female
5.314400E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Patient age information is not available for 10 samples.
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Comparison Statistical significance
Normal-vs-Age(21-40Yrs)
6.837100E-04
Normal-vs-Age(41-60Yrs)
7.92080000000528E-05
Normal-vs-Age(61-80Yrs)
1.87299953324782E-10
Normal-vs-Age(81-100Yrs)
2.044000E-02
Age(21-40Yrs)-vs-Age(41-60Yrs)
1.510990E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)
7.608600E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)
9.100000E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)
4.738200E-03
Age(41-60Yrs)-vs-Age(81-100Yrs)
3.357600E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)
7.163000E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
PR, ER or HER2 status by IHC is not available/not evaluated/ambiguous for 380 sample.
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Comparison Statistical significance
Normal-vs-Luminal
<1E-12
Normal-vs-HER2 Positive
8.917600E-01
Normal-vs-TNBC
1.935650E-03
Luminal-vs-HER2 Positive
3.217600E-04
Luminal-vs-TNBC
1.62447832963153E-12
HER2 Positive-vs-TNBC
5.633600E-02
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Menopause status is not available for 96 samples. Thirty four samples with intermediate menopause status are not considered in the above plot.
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Comparison Statistical significance
Normal-vs-Pre-Menopause
2.23139999999677E-06
Normal-vs-Peri-Menopause
9.961700E-02
Normal-vs-Post-Menopause
6.7516999768813E-09
Pre-Menopause-vs-Peri-Menopause
3.181200E-01
Pre-Menopause-vs-Post-Menopause
5.971200E-01
Peri-Menopause-vs-Post-Menopause
4.391800E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
BRCA : Breast invasive carcinoma
Subtype descriptions TNBC-BL1 TNBC Basal-like 1
TNBC-BL2 TNBC Basal-like 2 TNBC-IM TNBC Immunomodulatory
TNBC-M TNBC Mesenchymal TNBC-MSL TNBC mesenchymal stem-like
TNBC-LAR TNBC luminal androgen receptor TNBC-UNS TNBC unspecified
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Comparison Statistical significance
Normal-vs-Luminal
<1E-12
Normal-vs-HER2Pos
8.917600E-01
Normal-vs-TNBC-BL1
7.639400E-01
Normal-vs-TNBC-BL2
1.950210E-02
Normal-vs-TNBC-IM
5.020400E-02
Normal-vs-TNBC-LAR
8.092200E-01
Normal-vs-TNBC-MSL
5.581200E-04
Normal-vs-TNBC-M
7.868300E-02
Normal-vs-TNBC-UNS
9.548100E-02
Luminal-vs-HER2Pos
3.217600E-04
Luminal-vs-TNBC-BL1
4.408500E-02
Luminal-vs-TNBC-BL2
5.558100E-03
Luminal-vs-TNBC-IM
1.581360E-04
Luminal-vs-TNBC-LAR
2.791400E-01
Luminal-vs-TNBC-MSL
2.442300E-03
Luminal-vs-TNBC-M
3.63920000000517E-05
Luminal-vs-TNBC-UNS
9.81100000000401E-05
HER2Pos-vs-TNBC-BL1
7.519400E-01
HER2Pos-vs-TNBC-BL2
1.495400E-01
HER2Pos-vs-TNBC-IM
7.300200E-02
HER2Pos-vs-TNBC-LAR
8.401600E-01
HER2Pos-vs-TNBC-MSL
3.674200E-02
HER2Pos-vs-TNBC-M
1.174990E-01
HER2Pos-vs-TNBC-UNS
1.435750E-01
TNBC-BL1-vs-TNBC-BL2
2.790800E-01
TNBC-BL1-vs-TNBC-IM
2.385800E-01
TNBC-BL1-vs-TNBC-LAR
7.398600E-01
TNBC-BL1-vs-TNBC-MSL
7.245600E-02
TNBC-BL1-vs-TNBC-M
3.728200E-01
TNBC-BL1-vs-TNBC-UNS
4.025600E-01
TNBC-BL2-vs-TNBC-IM
9.492600E-01
TNBC-BL2-vs-TNBC-LAR
3.971600E-01
TNBC-BL2-vs-TNBC-MSL
4.026000E-01
TNBC-BL2-vs-TNBC-M
8.469200E-01
TNBC-BL2-vs-TNBC-UNS
7.657800E-01
TNBC-IM-vs-TNBC-LAR
3.779000E-01
TNBC-IM-vs-TNBC-MSL
4.560200E-01
TNBC-IM-vs-TNBC-M
7.618000E-01
TNBC-IM-vs-TNBC-UNS
6.726000E-01
TNBC-LAR-vs-TNBC-MSL
2.153000E-01
TNBC-LAR-vs-TNBC-M
4.447200E-01
TNBC-LAR-vs-TNBC-UNS
4.702200E-01
TNBC-MSL-vs-TNBC-M
3.519800E-01
TNBC-MSL-vs-TNBC-UNS
2.851800E-01
TNBC-M-vs-TNBC-UNS
9.079600E-01
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Tumor histology is not available for 3 samples.
Subtype descriptions IDC Infiltrating Ductal Carcinoma
ILC Infiltrating Lobular Carcinoma Mixed Mixed histology
Mucinous Mucinous Carcinoma Medullary Medullary Carcinoma
Metaplastic Metaplastic Carcinoma INOS Infiltrating Carcinoma NOS
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Comparison Statistical significance
Normal-vs-IDC
2.97839974905401E-10
Normal-vs-ILC
4.398100E-03
Normal-vs-Mixed
1.69224999999606E-05
Normal-vs-Other
1.484300E-02
Normal-vs-Mucinous
3.123800E-01
Normal-vs-Metaplastic
3.818400E-02
Normal-vs-INOS
N/A
Normal-vs-Medullary
8.661600E-02
IDC-vs-ILC
7.227900E-02
IDC-vs-Mixed
3.478200E-02
IDC-vs-Other
8.823000E-01
IDC-vs-Mucinous
5.351400E-01
IDC-vs-Metaplastic
3.724900E-03
IDC-vs-INOS
N/A
IDC-vs-Medullary
5.135500E-03
ILC-vs-Mixed
2.401700E-03
ILC-vs-Other
4.576400E-01
ILC-vs-Mucinous
9.160600E-01
ILC-vs-Metaplastic
4.936100E-03
ILC-vs-INOS
N/A
ILC-vs-Medullary
9.382900E-03
Mixed-vs-Other
2.634300E-02
Mixed-vs-Mucinous
1.858270E-02
Mixed-vs-Metaplastic
2.3409999999946E-05
Mixed-vs-INOS
N/A
Mixed-vs-Medullary
2.243200E-03
Other-vs-Mucinous
5.623800E-01
Other-vs-Metaplastic
1.804570E-03
Other-vs-INOS
N/A
Other-vs-Medullary
3.261600E-03
Mucinous-vs-Metaplastic
1.198160E-02
Mucinous-vs-INOS
N/A
Mucinous-vs-Medullary
1.296580E-01
Metaplastic-vs-INOS
N/A
Metaplastic-vs-Medullary
3.264600E-01
INOS-vs-Medullary
N/A
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Nodal metastais status is not available for 2 samples and cancer in nearby lymph nodes cannot be measured (NX) in 20 samples.
pathologic_N descriptions N0 No regional lymph node metastasis
N1 Metastases in 1 to 3 axillary lymph nodes N2 Metastases in 4 to 9 axillary lymph nodes
N3 Metastases in 10 or more axillary lymph nodes
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Comparison Statistical significance
Normal-vs-N0
3.14729999995045E-06
Normal-vs-N1
4.56049999986163E-08
Normal-vs-N2
4.91859999995903E-06
Normal-vs-N3
7.903500E-02
N0-vs-N1
1.217550E-01
N0-vs-N2
4.837700E-02
N0-vs-N3
5.899600E-01
N1-vs-N2
4.439800E-01
N1-vs-N3
1.929390E-01
N2-vs-N3
7.733900E-02
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
ChIP-seq data
Correlated genes
DepMap
BRCA : Breast invasive carcinoma Note
Whole exome sequencing data is not available for 65 samples.
TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison Statistical significance
Normal-vs-TP53-Mutant
3.978000E-01
Normal-vs-TP53-NonMutant
1.62947433324234E-12
TP53-Mutant-vs-TP53-NonMutant
1.52299950428869E-10
Pan-cancer view
Methylation
Survival
Protein Exp (CPTAC)
Correlated genes
DepMap
