POLE2 expression based on
BLCA : Bladder urothelial carcinoma
Comparison Statistical significance Normal-vs-Primary 1.11022302462516E-16
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Cancer stage information is not available for 8 samples.
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Comparison Statistical significance
Normal-vs-Stage1
6.027000E-01
Normal-vs-Stage2
1.62525548574877E-12
Normal-vs-Stage3
<1E-12
Normal-vs-Stage4
1.62458935193399E-12
Stage1-vs-Stage2
1.993790E-01
Stage1-vs-Stage3
1.380610E-01
Stage1-vs-Stage4
1.564420E-01
Stage2-vs-Stage3
5.076400E-01
Stage2-vs-Stage4
8.956200E-01
Stage3-vs-Stage4
3.992400E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Patient race information is not available for 22 samples.
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Comparison Statistical significance
Normal-vs-Caucasian
1.62458935193399E-12
Normal-vs-AfricanAmerican
5.16670000116903E-08
Normal-vs-Asian
8.12520000000871E-05
Caucasian-vs-AfricanAmerican
1.514260E-02
Caucasian-vs-Asian
1.602200E-03
AfricanAmerican-vs-Asian
1.018510E-04
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Patient gender information is not available for 6 samples.
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Comparison Statistical significance
Normal-vs-Male
1.62447832963153E-12
Normal-vs-Female
2.22044604925031E-16
Male-vs-Female
1.946950E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Patient BMI information is not available for 54 samples.
Descriptions Normal weight BMI greater than equal to 18.5 and BMI less than 25
Extereme weight
BMI greater than equal to 25 and BMI less than 30 Obese BMI greater than equal to 30 and BMI less than 40
Extreme Obese
BMI greater than 40
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Comparison Statistical significance
Normal-vs-Normal_Weight
1.62536650805123E-12
Normal-vs-Extreme_Weight
<1E-12
Normal-vs-Obese
2.16771045558062E-12
Normal-vs-Extreme_Obese
9.957500E-03
Normal_Weight-vs-Extreme_Weight
3.594000E-01
Normal_Weight-vs-Obese
6.981200E-01
Normal_Weight-vs-Extreme_Obese
4.932000E-01
Extreme_Weight-vs-Obese
2.273000E-01
Extreme_Weight-vs-Extreme_Obese
3.038800E-01
Obese-vs-Extreme_Obese
5.400400E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Patient age information is not available for 6 samples.
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Comparison Statistical significance
Normal-vs-Age(21-40Yrs)
8.730200E-02
Normal-vs-Age(41-60Yrs)
1.99840144432528E-15
Normal-vs-Age(61-80Yrs)
1.62447832963153E-12
Normal-vs-Age(81-100Yrs)
1.25610000178966E-08
Age(21-40Yrs)-vs-Age(41-60Yrs)
<1E-12
Age(21-40Yrs)-vs-Age(61-80Yrs)
1.62447832963153E-12
Age(21-40Yrs)-vs-Age(81-100Yrs)
4.2326031568507E-11
Age(41-60Yrs)-vs-Age(61-80Yrs)
9.925200E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)
4.696200E-02
Age(61-80Yrs)-vs-Age(81-100Yrs)
1.870100E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Smoking status is not available for 19 samples.
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Comparison Statistical significance
Normal-vs-Non smoker
7.54951656745106E-14
Normal-vs-Smoker
2.00617300549766E-13
Normal-vs-Reformed smoker1
1.62470037423645E-12
Normal-vs-Reformed smoker2
1.62803104331033E-12
Non smoker-vs-Smoker
8.120200E-01
Non smoker-vs-Reformed smoker1
7.803900E-02
Non smoker-vs-Reformed smoker2
2.765200E-01
Smoker-vs-Reformed smoker1
1.378390E-01
Smoker-vs-Reformed smoker2
4.046200E-01
Reformed smoker1-vs-Reformed smoker2
4.903000E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma
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Comparison Statistical significance
Normal-vs-ARID1A-mutant
2.89956947341352E-12
Normal-vs-ARID1A-nonmutant
<1E-12
ARID1A-mutant-vs-ARID1A-nonmutant
2.936200E-01
Visualize Survival
DepMap
BLCA : Bladder urothelial carcinoma Note
Histological subtype information is not available for 5 samples.
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Comparison Statistical significance
Normal-vs-Papillary tumors
1.93622895494627E-13
Normal-vs-NonPapillary tumors
<1E-12
Papillary tumors-vs-NonPapillary tumors
6.784500E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma BLCA subtypes: Robertson AG et al, Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2017 Oct 19;171(3):540-556.e25
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Comparison Statistical significance
Normal-vs-Neuronal
1.56457999999082E-05
Normal-vs-Basal squamous
<1E-12
Normal-vs-Luminal
3.789999999948E-06
Normal-vs-Luminal_Infiltrated
1.08410003196724E-09
Normal-vs-Luminal_Papillary
1.18349774425042E-13
Neuronal-vs-Basal squamous
7.565700E-02
Neuronal-vs-Luminal
1.641280E-03
Neuronal-vs-Luminal_Infiltrated
1.098050E-03
Neuronal-vs-Luminal_Papillary
3.922600E-03
Basal squamous-vs-Luminal
4.849200E-04
Basal squamous-vs-Luminal_Infiltrated
5.00870012132282E-10
Basal squamous-vs-Luminal_Papillary
3.65909999999747E-06
Luminal-vs-Luminal_Infiltrated
7.927400E-01
Luminal-vs-Luminal_Papillary
2.973400E-01
Luminal_Infiltrated-vs-Luminal_Papillary
7.769700E-02
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma Note
Nodal metastais status is not available for 6 samples and cancer in nearby lymph nodes cannot be measured (NX) in 36 samples.
pathologic_N descriptions N0 No regional lymph node metastasis
N1 Metastases in 1 to 3 axillary lymph nodes N2 Metastases in 4 to 9 axillary lymph nodes
N3 Metastases in 10 or more axillary lymph nodes
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Comparison Statistical significance
Normal-vs-N0
1.62447832963153E-12
Normal-vs-N1
2.17870055330138E-10
Normal-vs-N2
4.58622029242406E-12
Normal-vs-N3
1.255650E-03
N0-vs-N1
4.348200E-01
N0-vs-N2
2.503600E-01
N0-vs-N3
9.839600E-01
N1-vs-N2
1.096440E-01
N1-vs-N3
7.159000E-01
N2-vs-N3
6.502600E-01
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
BLCA : Bladder urothelial carcinoma TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison Statistical significance
Normal-vs-TP53-Mutant
1.62447832963153E-12
Normal-vs-TP53-NonMutant
1.3944401189292E-13
TP53-Mutant-vs-TP53-NonMutant
2.04360000033432E-07
Pan-cancer view
Methylation
Survival
Correlated genes
DepMap
