METTL3 expression based on
HNSC : Head and Neck squamous cell carcinoma
Comparison Statistical significance Normal-vs-Primary 1.62447832963153E-12
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Cancer stage information is not available for 76 samples.
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Comparison Statistical significance
Normal-vs-Stage1
7.80860000000327E-05
Normal-vs-Stage2
5.9367000204702E-10
Normal-vs-Stage3
1.19999565839635E-11
Normal-vs-Stage4
1.62447832963153E-12
Stage1-vs-Stage2
9.279400E-01
Stage1-vs-Stage3
4.032400E-01
Stage1-vs-Stage4
3.175600E-01
Stage2-vs-Stage3
1.825970E-01
Stage2-vs-Stage4
1.073390E-01
Stage3-vs-Stage4
9.671000E-01
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Patient race information is not available for 16 samples and two samples releted to Amerian Indian is not considered in the plot.
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Comparison Statistical significance
Normal-vs-Caucasian
1.62436730732907E-12
Normal-vs-AfricanAmerican
1.15160003755221E-09
Normal-vs-Asian
7.075500E-03
Caucasian-vs-AfricanAmerican
7.373800E-01
Caucasian-vs-Asian
5.673200E-01
AfricanAmerican-vs-Asian
6.590400E-01
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Patient gender information is not available for 1 sample.
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Comparison Statistical significance
Normal-vs-Male
<1E-12
Normal-vs-Female
1.96442861977175E-12
Male-vs-Female
2.070300E-02
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Patient age information is not available for 2 samples and one sample from patient aged below 21 years not considered in the above plot.
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Comparison Statistical significance
Normal-vs-Age(21-40Yrs)
1.237550E-03
Normal-vs-Age(41-60Yrs)
1.62447832963153E-12
Normal-vs-Age(61-80Yrs)
<1E-12
Normal-vs-Age(81-100Yrs)
8.07550000000434E-05
Age(21-40Yrs)-vs-Age(41-60Yrs)
8.831000E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)
8.836800E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)
6.196000E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)
9.340400E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)
5.614200E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)
5.680800E-01
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Tumor grade information is not available for 5 samples and undetermined for 18 samples.
Subtype descriptions Grade 1 Well differentiated (low grade)
Grade 2 Moderately differentiated (intermediate grade) Grade 3 Poorly differentiated (high grade)
Grade 4 Undifferentiated (high grade)
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Comparison Statistical significance
Normal-vs-Grade 1
4.83579999999151E-06
Normal-vs-Grade 2
1.62447832963153E-12
Normal-vs-Grade 3
1.62814206561279E-12
Normal-vs-Grade 4
6.811800E-04
Grade 1-vs-Grade 2
9.58589999999759E-05
Grade 1-vs-Grade 3
2.575200E-04
Grade 1-vs-Grade 4
2.23950000000084E-05
Grade 2-vs-Grade 3
5.811400E-01
Grade 2-vs-Grade 4
4.366300E-02
Grade 3-vs-Grade 4
7.833900E-02
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
HPV status is not available for 399 samples.
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Comparison Statistical significance
Normal-vs-HPV+ve
6.77125022718883E-12
Normal-vs-HPV-ve
9.44719968920538E-10
HPV+ve-vs-HPV-ve
1.260420E-02
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Nodal metastais status is not available for 25 samples and cancer in nearby lymph nodes cannot be measured (NX) in 75 samples.
pathologic_N descriptions N0 No regional lymph node metastasis
N1 Metastases in 1 to 3 axillary lymph nodes N2 Metastases in 4 to 9 axillary lymph nodes
N3 Metastases in 10 or more axillary lymph nodes
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Comparison Statistical significance
Normal-vs-N0
1.6610046671417E-12
Normal-vs-N1
1.32269994956857E-09
Normal-vs-N2
4.379200E-03
Normal-vs-N3
3.498500E-03
N0-vs-N1
9.503400E-01
N0-vs-N2
9.011600E-01
N0-vs-N3
5.326200E-01
N1-vs-N2
9.067600E-01
N1-vs-N3
4.331200E-01
N2-vs-N3
3.878200E-01
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
HPV status is not available for 6 samples.
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Comparison Statistical significance
Normal-vs-HPV+ve
1.62447832963153E-12
Normal-vs-HPV-ve
1.62447832963153E-12
HPV+ve-vs-HPV-ve
1.760740E-03
Human papilloma virus (HPV) status and viral subtypes were assessed independently at the Broad Institute by DNA sequencing and PathSeq algorithm: Campbell JD et al, Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. Cell Rep. 2018 Apr 3; 23(1): 194-212.e6
Pan-cancer view
Methylation
Survival
Correlated genes
HNSC : Head and Neck squamous cell carcinoma Note
Whole exome sequencing data is not available for 18 samples.
TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data
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Comparison Statistical significance
Normal-vs-TP53-Mutant
<1E-12
Normal-vs-TP53-NonMutant
1.62447832963153E-12
TP53-Mutant-vs-TP53-NonMutant
9.325400E-01
Pan-cancer view
Methylation
Survival
Correlated genes
