UALCAN

Select cancer

GLS expression based on

LUAD : Lung adenocarcinoma

Comparison	Statistical significance
Normal-vs-Primary	2.498500E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Cancer stage information is not available for 3 samples.

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Comparison	Statistical significance
Normal-vs-Stage1	1.965820E-01
Normal-vs-Stage2	4.173800E-02
Normal-vs-Stage3	3.682600E-01
Normal-vs-Stage4	7.647600E-01
Stage1-vs-Stage2	1.973020E-01
Stage1-vs-Stage3	7.426000E-01
Stage1-vs-Stage4	8.637200E-01
Stage2-vs-Stage3	5.212600E-01
Stage2-vs-Stage4	3.149000E-01
Stage3-vs-Stage4	7.017800E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Patient race information is not available for 68 samples and one American Indian sample not considered in the above plot.

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Comparison	Statistical significance
Normal-vs-Caucasian	1.020190E-01
Normal-vs-AfricanAmerican	1.873770E-01
Normal-vs-Asian	6.009000E-01
Caucasian-vs-AfricanAmerican	3.107800E-01
Caucasian-vs-Asian	4.649000E-01
AfricanAmerican-vs-Asian	1.853630E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Patient gender information is not available for 1 sample.

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Comparison	Statistical significance
Normal-vs-Male	5.053200E-01
Normal-vs-Female	1.012430E-02
Male-vs-Female	1.229410E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Patient age information is not available for 21 samples.

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Comparison	Statistical significance
Normal-vs-Age(21-40Yrs)	8.589600E-01
Normal-vs-Age(41-60Yrs)	8.091700E-02
Normal-vs-Age(61-80Yrs)	1.196590E-01
Normal-vs-Age(81-100Yrs)	4.950000E-01
Age(21-40Yrs)-vs-Age(41-60Yrs)	6.991400E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)	7.727200E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)	7.252600E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)	5.687000E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)	9.624400E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)	8.202200E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Smoking status is not available for 15 samples.

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Comparison	Statistical significance
Normal-vs-Non smoker	6.603400E-01
Normal-vs-Smoker	5.705800E-01
Normal-vs-Reformed smoker1	5.290300E-02
Normal-vs-Reformed smoker2	2.001400E-01
Non smoker-vs-Smoker	9.036000E-01
Non smoker-vs-Reformed smoker1	1.763620E-01
Non smoker-vs-Reformed smoker2	4.793200E-01
Smoker-vs-Reformed smoker1	2.246000E-01
Smoker-vs-Reformed smoker2	5.682000E-01
Reformed smoker1-vs-Reformed smoker2	4.902600E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Subtype descriptions
NOS	Lung Adenocarcinoma-Not Otherwise Specified (NOS)	Mixed	Lung Adenocarcinoma Mixed subtype
ClearCell	Lung Clear Cell Adenocarcinoma	LBC-Nonmucinous	Lung Bronchioloalveolar Carcinoma Non mucinous
SolidPatternPredominant	Lung Solid Pattern Predominant Adenocarcinoma	Acinar	Lung Acinar Adenocarcinoma
LBC-Mucinous	Lung Bronchioloalveolar Carcinoma Mucinous	Mucinous	Mucinous (Colloid) Carcinoma
Papillary	Lung Papillary Adenocarcinoma	Mucinous	Lung Mucinous Adenocarcinoma
Micropapillary	Lung Micropapillary Adenocarcinoma	SignetRing	Lung Signet Ring Adenocarcinoma

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Comparison	Statistical significance
Normal-vs-NOS	3.535800E-03
Normal-vs-Mixed	6.268800E-01
Normal-vs-ClearCell	1.780100E-03
Normal-vs-LBC-NonMucinous	6.057200E-01
Normal-vs-SolidPatternPredominant	6.839400E-01
Normal-vs-Acinar	7.006600E-01
Normal-vs-LBC-Mucinous	2.348600E-01
Normal-vs-Mucinous carcinoma	1.22669999713665E-08
Normal-vs-Papillary	1.597390E-01
Normal-vs-Mucinous	2.224300E-03
Normal-vs-Micropapillary	9.976400E-03
Normal-vs-SignetRing	N/A
NOS-vs-Mixed	2.303600E-01
NOS-vs-ClearCell	3.957000E-01
NOS-vs-LBC-NonMucinous	4.393800E-01
NOS-vs-SolidPatternPredominant	9.489200E-01
NOS-vs-Acinar	4.416800E-01
NOS-vs-LBC-Mucinous	5.616300E-02
NOS-vs-Mucinous carcinoma	5.37858646509903E-12
NOS-vs-Papillary	1.048410E-02
NOS-vs-Mucinous	4.037800E-01
NOS-vs-Micropapillary	9.773700E-02
NOS-vs-SignetRing	N/A
Mixed-vs-ClearCell	4.855200E-01
Mixed-vs-LBC-NonMucinous	8.874600E-01
Mixed-vs-SolidPatternPredominant	7.112400E-01
Mixed-vs-Acinar	9.484000E-01
Mixed-vs-LBC-Mucinous	1.861800E-01
Mixed-vs-Mucinous carcinoma	4.16440000000629E-05
Mixed-vs-Papillary	1.453200E-01
Mixed-vs-Mucinous	4.950600E-01
Mixed-vs-Micropapillary	7.001400E-01
Mixed-vs-SignetRing	N/A
ClearCell-vs-LBC-NonMucinous	2.385200E-01
ClearCell-vs-SolidPatternPredominant	4.611800E-01
ClearCell-vs-Acinar	2.923000E-01
ClearCell-vs-LBC-Mucinous	4.057200E-01
ClearCell-vs-Mucinous carcinoma	6.366000E-01
ClearCell-vs-Papillary	5.417600E-01
ClearCell-vs-Mucinous	8.784800E-01
ClearCell-vs-Micropapillary	1.418170E-03
ClearCell-vs-SignetRing	N/A
LBC-NonMucinous-vs-SolidPatternPredominant	6.873200E-01
LBC-NonMucinous-vs-Acinar	9.535600E-01
LBC-NonMucinous-vs-LBC-Mucinous	3.122400E-01
LBC-NonMucinous-vs-Mucinous carcinoma	3.160800E-03
LBC-NonMucinous-vs-Papillary	1.712630E-01
LBC-NonMucinous-vs-Mucinous	2.479200E-01
LBC-NonMucinous-vs-Micropapillary	9.187200E-01
LBC-NonMucinous-vs-SignetRing	N/A
SolidPatternPredominant-vs-Acinar	6.834600E-01
SolidPatternPredominant-vs-LBC-Mucinous	4.520200E-01
SolidPatternPredominant-vs-Mucinous carcinoma	2.842800E-01
SolidPatternPredominant-vs-Papillary	4.779000E-01
SolidPatternPredominant-vs-Mucinous	4.679000E-01
SolidPatternPredominant-vs-Micropapillary	8.038400E-01
SolidPatternPredominant-vs-SignetRing	N/A
Acinar-vs-LBC-Mucinous	3.738200E-01
Acinar-vs-Mucinous carcinoma	8.901800E-03
Acinar-vs-Papillary	2.168800E-01
Acinar-vs-Mucinous	3.022600E-01
Acinar-vs-Micropapillary	8.670400E-01
Acinar-vs-SignetRing	N/A
LBC-Mucinous-vs-Mucinous carcinoma	3.069000E-01
LBC-Mucinous-vs-Papillary	9.083000E-01
LBC-Mucinous-vs-Mucinous	4.243600E-01
LBC-Mucinous-vs-Micropapillary	1.197250E-01
LBC-Mucinous-vs-SignetRing	N/A
Mucinous carcinoma-vs-Papillary	1.084600E-01
Mucinous carcinoma-vs-Mucinous	7.100200E-01
Mucinous carcinoma-vs-Micropapillary	6.45689999999588E-05
Mucinous carcinoma-vs-SignetRing	N/A
Papillary-vs-Mucinous	5.582000E-01
Papillary-vs-Micropapillary	4.163900E-02
Papillary-vs-SignetRing	N/A
Mucinous-vs-Micropapillary	4.184200E-04
Mucinous-vs-SignetRing	N/A
Micropapillary-vs-SignetRing	N/A

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Nodal metastais status is not available for 1 sample and cancer in nearby lymph nodes cannot be measured (NX) in 11 samples.

pathologic_N descriptions
N0	No regional lymph node metastasis	N1	Metastases in 1 to 3 axillary lymph nodes
N2	Metastases in 4 to 9 axillary lymph nodes	N3	Metastases in 10 or more axillary lymph nodes

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Comparison	Statistical significance
Normal-vs-N0	2.008600E-01
Normal-vs-N1	5.473900E-02
Normal-vs-N2	3.610400E-01
Normal-vs-N3	5.873600E-01
N0-vs-N1	2.238800E-01
N0-vs-N2	6.807000E-01
N0-vs-N3	1.313180E-01
N1-vs-N2	6.363800E-01
N1-vs-N3	2.883200E-01
N2-vs-N3	3.118800E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Whole exome sequencing data is not available for 3 samples.

TP53 mutation status is obtained from TCGA whole exome sequencing data. We downloaded Mutation Annotation Format (MAF) files (derived from VarScan2) from Genomic Data Commons portal. The sample with/without TP53 mutation were matched with RNA-seq data

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Comparison	Statistical significance
Normal-vs-TP53-Mutant	3.197500E-03
Normal-vs-TP53-NonMutant	6.253200E-01
TP53-Mutant-vs-TP53-NonMutant	3.198300E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

GLS expression based on

LUAD : Lung adenocarcinoma

Comparison	Statistical significance
Normal-vs-Primary	2.498500E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Cancer stage information is not available for 3 samples.

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Comparison	Statistical significance
Normal-vs-Stage1	1.965820E-01
Normal-vs-Stage2	4.173800E-02
Normal-vs-Stage3	3.682600E-01
Normal-vs-Stage4	7.647600E-01
Stage1-vs-Stage2	1.973020E-01
Stage1-vs-Stage3	7.426000E-01
Stage1-vs-Stage4	8.637200E-01
Stage2-vs-Stage3	5.212600E-01
Stage2-vs-Stage4	3.149000E-01
Stage3-vs-Stage4	7.017800E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Patient race information is not available for 68 samples and one American Indian sample not considered in the above plot.

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Comparison	Statistical significance
Normal-vs-Caucasian	1.020190E-01
Normal-vs-AfricanAmerican	1.873770E-01
Normal-vs-Asian	6.009000E-01
Caucasian-vs-AfricanAmerican	3.107800E-01
Caucasian-vs-Asian	4.649000E-01
AfricanAmerican-vs-Asian	1.853630E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Patient gender information is not available for 1 sample.

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Comparison	Statistical significance
Normal-vs-Male	5.053200E-01
Normal-vs-Female	1.012430E-02
Male-vs-Female	1.229410E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Patient age information is not available for 21 samples.

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Comparison	Statistical significance
Normal-vs-Age(21-40Yrs)	8.589600E-01
Normal-vs-Age(41-60Yrs)	8.091700E-02
Normal-vs-Age(61-80Yrs)	1.196590E-01
Normal-vs-Age(81-100Yrs)	4.950000E-01
Age(21-40Yrs)-vs-Age(41-60Yrs)	6.991400E-01
Age(21-40Yrs)-vs-Age(61-80Yrs)	7.727200E-01
Age(21-40Yrs)-vs-Age(81-100Yrs)	7.252600E-01
Age(41-60Yrs)-vs-Age(61-80Yrs)	5.687000E-01
Age(41-60Yrs)-vs-Age(81-100Yrs)	9.624400E-01
Age(61-80Yrs)-vs-Age(81-100Yrs)	8.202200E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Smoking status is not available for 15 samples.

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Comparison	Statistical significance
Normal-vs-Non smoker	6.603400E-01
Normal-vs-Smoker	5.705800E-01
Normal-vs-Reformed smoker1	5.290300E-02
Normal-vs-Reformed smoker2	2.001400E-01
Non smoker-vs-Smoker	9.036000E-01
Non smoker-vs-Reformed smoker1	1.763620E-01
Non smoker-vs-Reformed smoker2	4.793200E-01
Smoker-vs-Reformed smoker1	2.246000E-01
Smoker-vs-Reformed smoker2	5.682000E-01
Reformed smoker1-vs-Reformed smoker2	4.902600E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Subtype descriptions
NOS	Lung Adenocarcinoma-Not Otherwise Specified (NOS)	Mixed	Lung Adenocarcinoma Mixed subtype
ClearCell	Lung Clear Cell Adenocarcinoma	LBC-Nonmucinous	Lung Bronchioloalveolar Carcinoma Non mucinous
SolidPatternPredominant	Lung Solid Pattern Predominant Adenocarcinoma	Acinar	Lung Acinar Adenocarcinoma
LBC-Mucinous	Lung Bronchioloalveolar Carcinoma Mucinous	Mucinous	Mucinous (Colloid) Carcinoma
Papillary	Lung Papillary Adenocarcinoma	Mucinous	Lung Mucinous Adenocarcinoma
Micropapillary	Lung Micropapillary Adenocarcinoma	SignetRing	Lung Signet Ring Adenocarcinoma

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Comparison	Statistical significance
Normal-vs-NOS	3.535800E-03
Normal-vs-Mixed	6.268800E-01
Normal-vs-ClearCell	1.780100E-03
Normal-vs-LBC-NonMucinous	6.057200E-01
Normal-vs-SolidPatternPredominant	6.839400E-01
Normal-vs-Acinar	7.006600E-01
Normal-vs-LBC-Mucinous	2.348600E-01
Normal-vs-Mucinous carcinoma	1.22669999713665E-08
Normal-vs-Papillary	1.597390E-01
Normal-vs-Mucinous	2.224300E-03
Normal-vs-Micropapillary	9.976400E-03
Normal-vs-SignetRing	N/A
NOS-vs-Mixed	2.303600E-01
NOS-vs-ClearCell	3.957000E-01
NOS-vs-LBC-NonMucinous	4.393800E-01
NOS-vs-SolidPatternPredominant	9.489200E-01
NOS-vs-Acinar	4.416800E-01
NOS-vs-LBC-Mucinous	5.616300E-02
NOS-vs-Mucinous carcinoma	5.37858646509903E-12
NOS-vs-Papillary	1.048410E-02
NOS-vs-Mucinous	4.037800E-01
NOS-vs-Micropapillary	9.773700E-02
NOS-vs-SignetRing	N/A
Mixed-vs-ClearCell	4.855200E-01
Mixed-vs-LBC-NonMucinous	8.874600E-01
Mixed-vs-SolidPatternPredominant	7.112400E-01
Mixed-vs-Acinar	9.484000E-01
Mixed-vs-LBC-Mucinous	1.861800E-01
Mixed-vs-Mucinous carcinoma	4.16440000000629E-05
Mixed-vs-Papillary	1.453200E-01
Mixed-vs-Mucinous	4.950600E-01
Mixed-vs-Micropapillary	7.001400E-01
Mixed-vs-SignetRing	N/A
ClearCell-vs-LBC-NonMucinous	2.385200E-01
ClearCell-vs-SolidPatternPredominant	4.611800E-01
ClearCell-vs-Acinar	2.923000E-01
ClearCell-vs-LBC-Mucinous	4.057200E-01
ClearCell-vs-Mucinous carcinoma	6.366000E-01
ClearCell-vs-Papillary	5.417600E-01
ClearCell-vs-Mucinous	8.784800E-01
ClearCell-vs-Micropapillary	1.418170E-03
ClearCell-vs-SignetRing	N/A
LBC-NonMucinous-vs-SolidPatternPredominant	6.873200E-01
LBC-NonMucinous-vs-Acinar	9.535600E-01
LBC-NonMucinous-vs-LBC-Mucinous	3.122400E-01
LBC-NonMucinous-vs-Mucinous carcinoma	3.160800E-03
LBC-NonMucinous-vs-Papillary	1.712630E-01
LBC-NonMucinous-vs-Mucinous	2.479200E-01
LBC-NonMucinous-vs-Micropapillary	9.187200E-01
LBC-NonMucinous-vs-SignetRing	N/A
SolidPatternPredominant-vs-Acinar	6.834600E-01
SolidPatternPredominant-vs-LBC-Mucinous	4.520200E-01
SolidPatternPredominant-vs-Mucinous carcinoma	2.842800E-01
SolidPatternPredominant-vs-Papillary	4.779000E-01
SolidPatternPredominant-vs-Mucinous	4.679000E-01
SolidPatternPredominant-vs-Micropapillary	8.038400E-01
SolidPatternPredominant-vs-SignetRing	N/A
Acinar-vs-LBC-Mucinous	3.738200E-01
Acinar-vs-Mucinous carcinoma	8.901800E-03
Acinar-vs-Papillary	2.168800E-01
Acinar-vs-Mucinous	3.022600E-01
Acinar-vs-Micropapillary	8.670400E-01
Acinar-vs-SignetRing	N/A
LBC-Mucinous-vs-Mucinous carcinoma	3.069000E-01
LBC-Mucinous-vs-Papillary	9.083000E-01
LBC-Mucinous-vs-Mucinous	4.243600E-01
LBC-Mucinous-vs-Micropapillary	1.197250E-01
LBC-Mucinous-vs-SignetRing	N/A
Mucinous carcinoma-vs-Papillary	1.084600E-01
Mucinous carcinoma-vs-Mucinous	7.100200E-01
Mucinous carcinoma-vs-Micropapillary	6.45689999999588E-05
Mucinous carcinoma-vs-SignetRing	N/A
Papillary-vs-Mucinous	5.582000E-01
Papillary-vs-Micropapillary	4.163900E-02
Papillary-vs-SignetRing	N/A
Mucinous-vs-Micropapillary	4.184200E-04
Mucinous-vs-SignetRing	N/A
Micropapillary-vs-SignetRing	N/A

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Nodal metastais status is not available for 1 sample and cancer in nearby lymph nodes cannot be measured (NX) in 11 samples.

pathologic_N descriptions
N0	No regional lymph node metastasis	N1	Metastases in 1 to 3 axillary lymph nodes
N2	Metastases in 4 to 9 axillary lymph nodes	N3	Metastases in 10 or more axillary lymph nodes

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Comparison	Statistical significance
Normal-vs-N0	2.008600E-01
Normal-vs-N1	5.473900E-02
Normal-vs-N2	3.610400E-01
Normal-vs-N3	5.873600E-01
N0-vs-N1	2.238800E-01
N0-vs-N2	6.807000E-01
N0-vs-N3	1.313180E-01
N1-vs-N2	6.363800E-01
N1-vs-N3	2.883200E-01
N2-vs-N3	3.118800E-01

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

LUAD : Lung adenocarcinoma

Note Whole exome sequencing data is not available for 3 samples.

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Comparison	Statistical significance
Normal-vs-TP53-Mutant	3.197500E-03
Normal-vs-TP53-NonMutant	6.253200E-01
TP53-Mutant-vs-TP53-NonMutant	3.198300E-02

Genecards
TargetScan
PubMed-Cancer
Human Protein Atlas
OpenTargets GTEx iPATH Drugbank

Select cancer

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

LUAD : Lung adenocarcinoma

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